When we examined macrophages incubated with 5 nmol/ml of the hydroperoxide by electron microscopy, however, the number of organelles was found to be increased and the electron density of the mitochondrial matrix was slightly decreased. Histamine suppressed interferon-g-induced interferon-mediated protein of IP-10 promoter activation in these cells, and the interferon-stimulated response element on the promoter was responsible for the suppression. Since the differentiation of monocytes into macrophages enhances H 1 and suppresses H 2 receptors expression. The mouse TACE mRNA was ubiquitously expressed, and was particularly high in the lung. Histamine as well as forskolin and dibutyryl cyclic AMP (Bt2-cAMP) stimulated the THP-1 monocytes to express the LOX-1 gene at the transcription level. Mast cell-derived histamine, TNF-α, and TGF-β1 act in concert to induce a transient increase in LOX-1 expression in human primary monocyte-derived macrophages. This review will highlight the biological and pharmacological characterization of histamine, histamine receptors, their antagonists/agonists, and implications in immune regulation and immunomodulation. Y., Takai, S., Yamada, K. and Ito, S. (1994) Biochem. The findings indicated that the expression of CCL22 in atherosclerosis models is under the influence of histamine. Therefore, although its etiology is complicated and multifactorial, histamine/HRs signaling has a close relationship with the development of metabolic syndrome. When BMSCs were pretreated with either histamine or degranulated human mast cells, they exhibited an enhanced IL-6-dependent antiapoptotic effect on neutrophil granulocytes. Methods: CCL22 expression was investigated in human carotid arteries and coronary arteries with bare metal stents. A deeper understanding of the molecular mechanisms involved in this modulatory effect could help us design better, more effective protocols to treat immune mediated diseases. and Sasaguri, Y. Modification of the cell surface in this way can alter the cell's responsiveness to its environment and release potent soluble regulatory factors. Our results suggest that CCL22 expression in monocytes is regulated by histamine, and that CCL22 is involved centrally in the development of human atherosclerotic lesions. Methods and results: Thus, although vesicular transport is the limiting factor determining quantal size of 5-HT and histamine release, intragranular association with the heparin matrix also plays a significant role. Substituting mepyramine for cimetidine resulted in small weals with an intense red colour. The histamine-mediated decrease in TNF-alpha synthesis was not affected by indomethacin, nor by diphenhydramine, an H1 receptor antagonist, but was reversed by cimetidine or ranitidine, H2 receptor antagonists, in a dose-dependent manner. We herein review diverse, key in vivo roles of histamine/HR signaling in the pathogenesis of metabolic syndrome. To approach the mechanism of the stimulating effect of linoleic acid hydroperoxide on the production of matrix metalloproteinases (MMPs) in human aortic intimal smooth muscle cells (ISMC), we investigated the effect of the hydroperoxide on the cytosolic level of Ca2+. The contributions of histamine (H1 or H2) receptor-mediated responses and, therefore, the effects of histamine blocking agents are unclear with regard to regulation of proximal epicardial and distal resistance coronary arteries. Branco ACCC, Yoshikawa FSY, Pietrobon AJ, Sato MN. Biophys. A luciferase promoter assay with U937 and Jurkat cells demonstrated that interleukin-4 (IL-4) inhibited the expression of the HDC gene. This paper summarizes the Part 1 of the proceedings of the 8th International Conference on Management and Rehabilitation of Chronic Respiratory Failure, held in Pescara, Italy, on 7 and 8 May, 2015. ... 21 Furthermore, vascular smooth muscle cells (SMCs) predominantly express H1R, which is activated by platelet-derived growth factor-BB (PDGF-BB), 21,22 and H1R mRNA also shows specific expression in endothelial cells (ECs) in atheromatous plaques. In contrast, the H2 blocker attenuated both epicardial dilation (6% below control) and flow response (31% above control) to the highest histamine dose. Immunohistochemical analysis of human atherosclerotic lesions revealed that macrophages and DCs express CCL22. Histamine regulates antigen-specific Th1 and Th2 cells, as well as related antibody isotype responses. In the presence of 15 nmol/ml of the hydroperoxide, macrophages showed the features of marked degeneration, while still retained phagocytotic activity to a considerable extent. The LOX-1-inducing activity potentially endows mast cells a hitherto unrecognized role in the regulation of innate immune reactions in atherogenesis. Homology analysis showed the highest similarity to M2 muscarinic acetylcholine receptors and overall low homology to all other biogenic amine receptors. CCL22 was distributed in sparse areas of vascular smooth muscle cells (VSMCs) and associated with M2-like macrophages. The switch of the predominant class of histamine receptors between H1 and H2 would modulate the effects of histamine on LOX-1 gene expression in monocytes and macrophages, and therefore, would play a certain role in the inflammatory aspects of atherogenesis. PCR reactions were performed with cDNA corresponding to 50 ng total RNA and primers designed to amplify the coding sequence of the histamine receptors. Histamine mediates many types of physiologic signals in multicellular organisms. Elevated CRP levels are positively associated with all-cause [77,78] and COPD-related mortality. Sequence analysis of the promoter of 223 Japanese subjects revealed that most had two alleles with 20, 21 or 22 d(CA) repeats, whereas six had one or two alleles with 14, 18 or 19 d(CA) repeats. Satoh, T., Sugama, K., Matsuo, A., Kato, S., Ito, S., Hatanaka, Gene expression changes in rat regenerating liver were detected by rat genome 230 2.0 array. In addition to the numerous roles of histamine in both the immune and nervous systems, previous studies have suggested that this bioamine might also be involved in bone metabolism. J.L., Wolfson, M.F., Castner, B.J., Stocking, K.L., Reddy, P., - Definition, Types & Function, What Are Fibroblasts? The increased adhesion was inhib- ited by anti-CD11b and anti-CD18 monoclonal antibodies (mAbs), but not by anti-CD11a and anti-CD54 (ICAM-1) mAbs. USA.gov. We examined the in vitro effects of histamine on interferon-induced protein of IP-10 production in human squamous cell carcinoma and melanoma. Run-on analysis demonstrated detectable levels of c-jun gene transcription in untreated HL-60 cells, and that exposure to TPA increases this rate 3.3-fold. The localization and expression of CCL22 and classical (M1)-like and M2-like macrophages in various human and mouse atherosclerotic lesions were investigated by immunohistochemical examination and quantitative real-time polymerase chain reaction. KW-4679 and ketotifen, antiallergic drugs with histamine H1 receptor antagonistic activity, potently inhibit the expression of E-selectin and ICAM-1.

- Definition & Explanation, Innate Immunity: Inflammation, Neutrophils & Natural Killer Cells, What Are Monocytes? The effects of intradermally administered histamine H1- and H2-receptor antagonists on the cutaneous responses--redness, weal, flare and itch--induced by intradermal injection of histamine were studied in man. Based on these observations, it is likely that introduction of BMSCs into a histamine-rich environment (such as any allergic setting) or pretreatment of these cells with synthetic histamine could have a significant modulatory effect on the therapeutic potential of BMSCs. Moreover, human monocytes have been shown to switch histamine receptor expression upon differentiation into macrophages by an upregulation of H 1 R and a downregulation of H 2 R [40, ... Histamine signals through four known histamine receptors (H1-4) which are differentially expressed on all immune cells, including monocytes and MDSCs. In contrast to the development of DCs, during macrophage differentiation from monocytes H1R is up-and H2R downregulated [49. Taken together, these results reveal that H2 signaling may be a novel target to alter the monocyte population in breast tumor models, and that targeting H2 on monocytes via oral ranitidine treatment impacts effective tumor immunity. Histamine is synthesized from L-histidine by histidine decarboxylase and is involved in a variety of physiologic responses, such as inflammation, type I allergy, gastric acid secretion and neurotransmission. E Nettis1, G F Calogiuri2, E Di Leo1, F Cardinale3, L Macchia1, A Ferrannini1, A Vacca1,41Section of Allergology and Clinical Immunology, Department of Internal Medicine and Infectious Diseases; 24th Pneumology Department, Pneumologic Hospital A Galateo, San Cesario di Lecce, Italy; 3Department of Biomedicina dell’Età Evolutiva, Pediatrics Unit “S Maggiore”; 4Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, ItalyAbstract: Levocetirizine is the pharmacologically active enantiomer of cetirizine. TE9 cells with low MMP-9 enzymatic activity had the number of d(CA) repeats shortened from 21 to 14 or 18. the dysregulation of lipid/bile acid/glucose metabolism. Histamine increased in a dose-dependent manner cellular cAMP content in L cells permanently transfected with this gene, and preincubation of the cells with the H2-selective antagonist cimetidine shifted the dose-response curve to the right. Among four subclasses of HRs, the expression profile of the main receptors (H1/2R) has been shown to be switched from H2R to H1R during monocyte to macrophage differentiation, and H1R is also predominant in smooth muscle and endothelial cells of atheromatous plaque. It is interesting that flow cytometric analysis revealed that ICAM-1 ex- pression on HT29 cells was not changed by TNF-a and histamine stimulation.


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