O}���r�K����ζ�0�j;X���.���Wݸ rh���b��ɸ��UA�]�S+Xv�"y�'�+)c"9'�Q\om����\8��> �~U[5R������7qgE�� I"j���i$�Q���E�>�>B�^+O�;��=&� This extension of StemMapper will also enable the user to upload transcriptomics data generated by different microarray or sequencing technologies.
Query panel (steps 1–4): After selecting all transcriptomic profiles for mouse (step 1), the 18 genes of interest were used as input (step 3) without the optional selection of pre-compiled marker genes (step 2), and the query was executed (step 4). INTRODUCTION. This table contains only a subset of MSC markers by tissue of origin. StemMapper's database was implemented using MySQL. Once the queried data is retrieved and processed, two main tabs are generated: Heatmaps and PCA Plot containing interactive plots for these visualizations, allowing the user to access detailed gene-centered or cell type-centered information. Future versions of StemMapper will include additional transcriptomics platforms, as discussed below. Commonly, the expression patterns of so-called marker genes have been used to define specific SC populations. StemMapper workflow using a set of genes associated with the differentiation of neural precursor cells into astrocytes. For example, a cell that has the receptor stem cell antigen – 1, on its surface, is identified as Sca-1. �J)�Ⱦ��u�|W=�$�!.s�,T �Sh5x�QjXnr-1�BXg�Ľ����&�z?7���8������GPӠ!i���0�V��&��|��X�\ ��K���E=TI��h��s��﫛g�㹊es{)h,o)Zt�T�?�܆���'ʑ]�uy��W]�TO�V �5 D��ug#o���$:kp?�)�^����?H03��� ��rڬ>@�fŮ�;��-^�ʺ(ד��`r�dz}@��m�KJ۶�6*�3��\� )ܠ��7���ʶ�iro��1���R afݾ ��� ^&>K�/q�L��8-^W��1,���j��T��ۗ L�!�M�\~�v%����$���c�'S��T���4ZR�(��9T���. 117 0 obj <> endobj The MySQL database is accessed via the Hibernate library. In the first step, the user selects the appropriate microarray platform (mouse or human data) and the datasets pertaining to the cell lineage(s) of interest. Stem cell markers are given short-hand names based on the molecules that … Similarly, clicking on the leaves of the dendrogram opens a window with details about the corresponding sample, together with relevant GEO links. Examination of the PCA plot shows that the 40 selected genes clearly separates neural cell lineage types (including olfactory bulb stem cells) from other lineages, indicating a strong discriminative potential. The salient need to facilitate exploration of the accumulated data has led to the development of StemMapper.

In principle, this wealth of data should provide a compelling basis for the dissection of molecular processes underlying cellular identity and lineage. Access and analysis of the growing amount of freely available transcriptomics datasets for SCs, however, are not trivial tasks. The ESC and Lineage Markers diagram provides an overview of ESC differentiation along lineage-specific pathways and links to products from CST.

The PrimeFaces library was used to extend the functionalities of JSF’s standard core and tag libraries. A structure model of CD133 proposed by Miraglia S. et al. Please check for further notifications by email. h�b```f``2a`a``�a�e@ ^F da�h`@�66����tgڞ�Ol�+��+���d-^��˰�zω�ǂ2n50����A=3�m��b��L�jJ����D/KM잓 ��g`�Ҍ@��A���P�g� ӛ> endobj 119 0 obj <> endobj 120 0 obj <>stream Step 5. H��T�o�0~�_q�)R���Dj������.g�s+G��(80(��qH��?�$���bCX��&I�CQ�|V|� b �1)�a���Dp���,Mg��@m]˶.p��@e�6e�ݣ1Eu>���jB����bmND�l1 x��'4��є? The training data included a diverse set of batches, which were in our case GEO series (GSE) and were selected to cover a broad range of SC types and experimental conditions (e.g. Accumulating evidence has established involvement of EMT in several biological processes including (but not limited to) embryonic and post-embryonic development, tissue regeneration/wound healing, stem cell homeostasis, and in pathophysiology of fibrosis and malignancies. Astrocytes are the most abundant cell type in the mammalian brain. The second and third steps consist of selecting the genes of interest, for which the expression values will be retrieved from the database to be analysed and visually inspected. �%��^�9��?��!�#�. Conventionally, markers used for mESCs, mouse embryonic carcinomas (ECs), or human EC cells, were exploited to identify undifferentiated human embryonic stem cells (hESCs) [10, 11].At the pre-implantation stage, murine embryos, human germ cells, and teratocarcinoma stem cells express certain molecular receptors known as Stage-Specific Embryonic Antigens (SSEA) on their membrane … The CSC hypothesis states that, although CSCs represent a rare population of cells within a tumor, their high tumorigenic capacity drives tumorigenesis.

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