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0.556 1.00001 Td Q ET (E-mail alerts)Tj endobj \251 2009 American Association for Cancer)Tj -6.38997 1 Td (doi:)Tj (\240 )Tj Acrobat Distiller 4.05 for Windows Classification of anticancer drugs based on their differential impacts on DCs ( A ) Each drug was tested at 5 different doses (0.1-10 μ M) for its efficacies to elevate YFP -15.44997 0 Td 0 g 0 0 1 rg (\240 )Tj /T1_3 1 Tf Just like scalpels, lasers, and electric currents are used in surgery, the weapons used to fight cancer in chemotherapy are a host of anti-cancer drugs. -6.00198 1 Td (\240 )Tj H���M�UI����~� �͇�1�3ZpcBO��ǂ7nԅ�$�BM�Q�!a=n��c&&�gC������@ $>���w������=3��o1���v��U�N��^\q ���a� ���ȰS @�Dd�) �m"2� �6v )Tj 130 0 obj -5.77898 0 Td (To order reprints of this article or to subscribe to the journal, contac\ t the AACR Publications)Tj endobj

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BT Chemotherapeutic agents, also referred to as antineoplastic agents, are used to directly or indirectly inhibit the proliferation of rapidly growing cells, typically in the context of malignancy.They are classified according to their mechanism of action and include alkylating agents, antimetabolites, topoisomerase inhibitors, and mitotic inhibitors. The cell cycle is a series of phases that all cells, both normal and cancerous, go through to form new cells. 9 0 0 9 132.91908 770 Tm 11 0 0 11 120.94202 479.99994 Tm (\240 )Tj BT ( )Tj (on October 10, 2020.

0 g /T1_0 1 Tf 0 1 TD 30.29194 1 Td 10 0 0 10 85.56992 567.99985 Tm (Department at)Tj (cancerres.aacrjournals.org )Tj 17 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/Type/Page>> Published OnlineFirst August 25, 2009. 39.57494 1 Td endobj ET (\240 )Tj BT endobj /T1_0 1 Tf (http://cancerres.aacrjournals.org/content/69/17/6978)Tj -30.29194 0 Td (Reprints and )Tj -6.85098 0 Td 0 1.00001 TD endobj 0 0 1 rg /T1_3 1 Tf BT /T1_0 1 Tf 0 1.00001 TD (Access the most recent supplemental material at:)Tj 29 0 obj

<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/Type/Page>> 127 0 obj (http://cancerres.aacrjournals.org/content/69/17/6978.full#related-urls)Tj 160 0 obj There are many kinds of chemo drugs. <>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/Type/Page>> endobj 540.0594177 0 0 68.6011963 22.4702911 666.3988037 cm ET

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0 0 m UK prices shown, other nationalities may qualify for reduced prices. 0 g <>/Font<>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/Type/Page>> 36 0 obj 11 0 0 11 120.94202 262.99997 Tm 11 0 0 11 120.94202 407.99997 Tm Most chemotherapy drugs kill cancer cells outright, or stop their reproduction and spread by inhibiting metabolic functions of the cancer cell. 23 0 obj /T1_0 1 Tf

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3B2 Total Publishing 6.06b/W Different types of chemo drugs work on different phases of the cell cycle. Chemotherapy drugs may be be classified as follows- Alkylating agents (or) DNA- damaging agents Alkylating agents act by chemically altering the cellular DNA.They add alkyl groups to … (\240 )Tj (pubs@aacr.org)Tj 10 0 0 10 30 459.99997 Tm endobj (\240 )Tj ET (Subscriptions)Tj 10 0 0 10 141 224.99985 Tm (10.1158/0008-5472.CAN-09-1101)Tj -3.44499 1.00001 Td 9 0 0 9 269.74257 1.99997 Tm

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28.90194 1 Td (Material)Tj (Supplementary)Tj /T1_2 1 Tf 50 0 obj 0 1 TD (\240 )Tj T* endobj [166 0 R 167 0 R 168 0 R 169 0 R 170 0 R 171 0 R 172 0 R 173 0 R] ET Preface: The development of effective drugs for the treatment of cancer represents a significant achievement beginning with the discovery of the antimetabolites and alkylating agents in the 1940s and 1950s.

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0 0 1 rg 11 0 0 11 120.94202 317.99997 Tm If this tutorial is part of the member benefit package, Fellows, Members, registered Trainees and Associates should sign in to access the tutorial. (\240 )Tj h��; �MD�� �&"�N m�a� ���ȰS @�Dd�) �m"2� �6v Classification of chemotherapy drugs. ( related to this article or journal. 11 0 0 11 120.94202 377.99997 Tm S 0 1.00001 TD /T1_2 1 Tf 13.46497 1 Td 10 0 0 10 141 369.99994 Tm ( Effects on Dendritic Cells)Tj ET 2009-08-25T19:23:02Z (Sign up to receive free email-alerts)Tj /T1_3 1 Tf (\240 )Tj ET 10 0 0 10 30 439.99997 Tm -3.50099 1 Td


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