Your healthcare provider will decide the time between doses as well as how many treatments you will receive. Thus, Daratumumab appears to be the ideal candidate to propose immunotherapy maintenance and reinforce the post-transplant immunomodulation strategy. See additional information. Darzalex will be given to you by your healthcare provider by intravenous (IV) infusion into your vein. The median expected overall survival (OS) in these patients is 9 months. Read our, ClinicalTrials.gov Identifier: NCT04024384, Interventional Cumulative incidence of chronic GVHD as assessed by NIH Consensus Criteria within the first 12 months after transplantation.
The major reason for treatment failure after allo-SCT for MM has become relapse, which is between 38% and 55%. Allogeneic stem cell transplantation (allo-SCT) remains the most reasonable treatment option, apart from palliative care, in patients with refractory or relapsed MM. The median 18-month PFS, OS and NRM were 33%, 63% and 10%, respectively. Study record managers: refer to the Data Element Definitions if submitting registration or results information. Quantify CD38+ cells from the bone marrow CD-138 negative fractions and acellular fractions, including T, NK, and monocyte subsets using pre- and on-daratumumab treatment samples by flow cytometry. T-cell replete haploidentical allo-SCT has now become feasible with the use of post-graft Cyclophosphamide, which reduces the risk of GVHD. Use the checklist in our guide to gather the information you'll Disease response rate at day +30, day +90 and 12 months after transplantation, Overall survival, at 12 months after transplantation, GVHD-free, at 12 months after transplantation, Relapse-free survival at 12 months after transplantation. For general information, Learn About Clinical Studies. * Psoriasis not requiring systemic treatment, Subject has known allergies, hypersensitivity, or intolerance to monoclonal antibodies or human proteins, or their excipients, Subject has history of primary immunodeficiency, Subject is seropositive for human immunodeficiency virus (HIV-1), Seropositive for hepatitis B (defined by a positive test for hepatitis B surface antigen [HBsAg]); subjects with resolved infection (I.e., subjects who are HBsAg negative but positive for antibodies to hepatitis B core antigen [anti-HBc] and/or antibodies to hepatitis B surface antigen [anti-HBs] must be screened using real-time polymerase chain reaction [PCR] measurement of hepatitis B virus [HBV] deoxyribonucleic acid [DNA] levels; those who are PCR positive will be excluded); EXCEPTION: Subjects with serologic finding suggestive of HBV vaccination (anti-HBs positivity as the only serologic marker) AND a known history of prior HBV vaccination, do not need to be tested for HBV DNA by PCR, Seropositive for hepatitis C (except in the setting of a sustained virologic response [SVR], defined as aviremia at least 12 weeks after completion of antiviral therapy), Subject has any one of the following: Lead Organization Daratumumab After Stem Cell Transplant in Treating Patients With Multiple Myeloma The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. In the prospective HOVON 76 trial, 43% patients stopped lenalidomide maintenance because of development of GVHD, 17% patients because of other adverse events, and 17% patients because of progression. Cancer can be treated through chemotherapy, a treatment of drugs that destroy cancer cells.

nerve damage causing tingling, numbness or. If differences in CD38 expression are found, investigate epigenetic changes in CD38 mRNA expression. Experts have praised certain foods for their ability to reduce cancer risks. pDLI can improve remission status in 54% of the patients and result in 5-year PFS of 79%.

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