ASCO Meetings T-cell-replete haploidentical HSCT with low-dose anti-T-lymphocyte globulin compared with matched sibling HSCT and unrelated HSCT, Risk-stratified outcomes of nonmyeloablative HLA-haploidentical BMT with high-dose posttransplantation cyclophosphamide, Female-versus-male alloreactivity as a model for minor histocompatibility antigens in hematopoietic stem cell transplantation, Long-term follow-up of haploidentical hematopoietic stem cell transplantation without in vitro T cell depletion for the treatment of leukemia: Nine years of experience at a single center, “No donor”? ASCO Connection TAPUR Study, Terms of Use | Privacy Policy | For the patients who underwent first transplantation, median OS was 25.6 months, and the patients with second transplantation had an OS of 6.5 months. Univariate analysis revealed significant association with male gender (OR 8.4; p=0.004), age >15 years at transplant (OR 4.2; p=0.04), pre-transplant high number of RCC (median 72 units vs 31 in non-PTE group; p<0.001) and platelets transfusions (median 249 events vs 66; p=0.001), ciclosporin-induced hypertension (OR 5.9; p=0.015) and viral hepatitis (OR 6.5; p=0.01). Long H, Lu ZG, Song CY, et al. In a series of 54 patients undergoing haploidentical donor transplantation (HAPLO) compared to those from a control group of patients receiving cells from matched or mismatched unrelated donors (URD) selected by diagnosis and stem cell source transplantation outcomes were compared. In 1968, attempts were successful for allo-HCT from a non-twin sibling donor.6 The first successful unrelated donor (UD) transplantation took place in 1973. Similarly, relative to haploidentical transplants risk of chronic GVHD was higher in URD without ATG and URD with ATG (p<0.0001). Long–term outcomes of HLA–haploidentical stem cell transplantation based on an FBCA conditioning regimen compared with those of HLA–identical sibling stem cell transplantation for haematologic malignancies. JCO Precision Oncology, ASCO Educational Book Despite the potency of the GVT effect, post-transplant persistence or recurrence of malignancy continues to be a major cause of treatment failure after allogeneic HCT. 2020 Jan;88:106266. doi: 10.1016/j.leukres.2019.106266. Group A, B and C were compared for outcome, disease free survival and rejection. All relationships are considered compensated. Van Besien K et al.,9 in their study of Haploidentical (haplo)-cord transplantation combined infusion of an umbilical cord blood (UCB) unit with CD34-selected cells usually from human leukocyte antigen (HLA) mismatched donors and suggested that initial rapid count recovery from the haplo-hematopoietic progenitors, is gradually replaced by durable engraftment from UCB progenitors thus benefitting overall outcomes5 Hence haploidentical SCT can also be used as a bridge to improving outcomes in patients undergoing UCB SCT thus achieving the best of both the worlds. How do we choose the best donor for T-cell-replete, HLA-haploidentical transplantation? Recent advances in haploidentical stem cell transplantation have enabled the use of human leukocyte antigen-half matched related donors for allogeneic stem cell transplantation and helped overcome one of the most important limitation in transplantation, which is donor availability, especially for the non-Caucasian population and mixed race individuals, extending allogeneic stem cell transplant for almost all patients in need. They observed encouraging results, with incidence of acute GVHD, chronic GVHD, and 1-year OS being 10%, 5%, and 69%, respectively (Table 1). Comparable post–relapse outcomes between haploidentical and matched related donor allogeneic stem cell transplantation.

Who is the best donor for a related HLA-haplotype-mismatched transplant? Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version | Opera | Privacy Policy, Haploidentical stem cell transplantation a mini review. 2019 Dec;25(12):2375-2382. doi: 10.1016/j.bbmt.2019.07.029.

A total of 19 patients had a non-myeloablative preparative regimen (NMA, 57%), 14 patients received a full myeloablative conditioning (MA, 43%). Raj et al32 reported the outcome of 55 patients who underwent haplo-HCT at four transplantation centers using RIC and PBSC grafts followed by PT/Cy. In another report, Raiola et al18 studied 50 patients, with the great majority having myeloid and a few having lymphoid malignancies.  | 


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