2015 Dec 01;33(12):3504-18.

The mission of induced Pluripotent Stem Cells (iPSC) Core is to accelerate stem cell research by providing investigators consultation, technical services and training in human pluripotent stem cell technology. U.S. Department of Health & Human Services, COVID-19 is an emerging, rapidly evolving situation, Get the latest public health information from CDC, Get the latest research information from NIH, Get the latest information and resources from NHLBI, NIH staff guidance on coronavirus (NIH Only), Obesity, Nutrition, and Physical Activity, NHLBI Diversity, Equity and Inclusion Statement, Customer Service/Center for Health Information. Facebook The promise of all stem cells for use in future therapies is exciting, but significant technical hurdles remain that will only be overcome through years of intensive research. 2015 Feb 01(96). New multiple sclerosis treatment trial compares stem cell transplantation to best available drugs NIH-funded study focuses on severe forms of relapsing MS. Scanning electron micrograph of a human T cell from the immune system of a healthy donor. Instagram NIH research is progressing on multiple fronts to learn more about the differences between the 3 stem cell types and to create patient-specific cells for in-depth study of many diseases. Transcriptome Dynamics of Developing Photoreceptors in Three-Dimensional Retina Cultures Recapitulates Temporal Sequence of Human Cone and Rod Differentiation Revealing Cell Surface Markers and Gene Networks. An agency of the U.S. Department of Health and Human Services, the NIH is the Federal focal point for health and medical research. Kaewkhaw R, Swaroop M, Homma K, Nakamura J, Brooks M, Kaya KD, Chaitankar V, Michael S, Tawa G, Zou J, Rao M, Zheng W, Cogliati T, Swaroop A. Additionally, the NIH Center for Regenerative Medicine (CRM) is a resource that provides infrastructure to accelerate the clinical translation of stem cell-based therapies—at any one time, around 100 clinical trials investigating the use of stem cells as therapies are ongoing at the NIH Clinical Center.

In addition to providing services and consultations to NIH researchers, the Core staff collaborate with investigators to work on custom and exploratory projects.

An Autologous Cell Based Therapy Using iPS Cell-Derived RPE, NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE, Using iPSC to model the neurological phenotype of alpha-dystroglycanopathie, NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES, iPSC-derived Human Hepatocytes: A Model for Treatment of Liver Disease, Towards cell therapy for FPD/AML with patient-specific iPS cells, Constructing Functional iPSC-derived RPE Tissue for Cell-based Therapy, Regenerative medicine using lineage reprogramming of tumor-specific T cells, Making neurons from FX iPSCs to study disease pathology and to screen for drugs, This page last reviewed on January 4, 2018, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892, U.S. Department of Health and Human Services, U.S. Department of Health & Human Services, Division of Program Coordination, Planning, and Strategic Initiatives (DPCPSI), HCS Research Collaboratory (NIH Collaboratory), NIH Director's Early Independence Award (EIA), NIH Director's Transformative Research Awards (TRA), The Human BioMolecular Atlas Program (HuBMAP), Knockout Mouse Phenotyping Program (KOMP2), Library of Integrated Network-Based Cellular Signatures (LINCS), Molecular Transducers of Physical Activity in Humans (MoTrPAC), Stimulating Peripheral Activity to Relieve Conditions (SPARC), Strengthening the Biomedical Research Workforce, Transformative High Resolution Cryo-Electron Microscopy (CryoEM), Current Common Fund Funding Opportunities, About the Office of Strategic Coordination, Get the latest public health information from CDC », Get the latest research information from NIH », NIH staff guidance on coronavirus (NIH Only) », NATIONAL HEART, LUNG, AND BLOOD INSTITUTE, Reprogramming and lineage differentiations of IPS cells from HIES patients, Targeted correction of human and mouse iPS cells for liver diseases, Preclinical Development of reprogrammed cells utilizing the rhesus macaque, An iPS cell system for the study of motor neuron disease, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES, Induction of pancreatic beta cell development in iPS cells by GLIS3, NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES, Gene Repaired Autologous iPSC to treat Chronic Granulomatous Disease, Mechanisms of AMD Initiation Using iPS Cell-Derived RPE, Stimulation of anti-glioma immune responses by iPS cell-derived microglia, NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES, Role of Epigenetic Regulators in iPS and SCNT-derived ESCs, iPSc to study and treat Gaucher disease and associated parkinsonism, Therapies for early onset retinal degeneration using iPS cell technology, NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT, iPS cells for the analysis and treatment of SLOS, a rare childhood disorder, Induced pluripotent stem cells to model telomere regulation and cell therapy, Development of iPS Cell-Based Disease Model of Niemann-Pick Disease Type C, Isolation of "homogeneous" human iPS cell populations, iPS cells for mechanistic and therapeutic studies of motor neuron disease, NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS, Induction of hair cell regeneration using induced pluripotent stem cells, Assessing the Smads2/3 dependent epigenetic landscape in iPSC, Development of a Reference Set of Comprehensively Characterized iPS cell li, Restoring Vision: Criteria for iPS Cell Derived Retinal Pigment Epithelia, Reprogramming tumor-specific T cells using iPS for cancer immunotherapy, NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH, Differentiation of human iPSCs into bone and cartilage, Validation of human GABA inter-neurons derived from iPS cells. Below are links to announcements and results of those initiatives, workshop reports and other resources. Induced pluripotent stem cells (iPSCs) technology is transforming biological research. Eradication of B-ALL using chimeric antigen receptor-expressing T cells targeting the TSLPR oncoprotein. Additionally, the NIH Center for Regenerative Medicine (CRM) is a resource that provides infrastructure to accelerate the clinical translation of stem cell-based therapies—at any one time, around 100 clinical trials investigating the use of stem cells as therapies are ongoing at the NIH Clinical Center. Stem Cells NIH Guidelines on Human Stem Cell Research, effective July 7, 2009, implement the Executive Order. Receive automatic alerts about NHLBI related news and highlights from across the Institute. View stem cell initiatives-related listings from the NIH Guide for Grants and Contracts, the official publication for NIH research grant policies, guidelines and funding opportunities. 2016 Apr 01;57(5):ORSFl1-ORSFl11. The NIH website offers health information for the public, scientists, researchers, medical professionals, patients, educators, Treatment Paradigms for Retinal and Macular Diseases Using 3-D Retina Cultures Derived From Human Reporter Pluripotent Stem Cell Lines. Prolyl hydroxylation regulates protein degradation, synthesis, and splicing in human induced pluripotent stem cell-derived cardiomyocytes. Francis KR, Ton AN, Xin Y, O'Halloran PE, Wassif CA, Malik N, Williams IM, Cluzeau CV, Trivedi NS, Pavan WJ, Cho W, Westphal H, Porter FD. Kaewkhaw R, Kaya KD, Brooks M, Homma K, Zou J, Chaitankar V, Rao M, Swaroop A. Stem Cell Research - Induced Pluripotent Stem Cell - Human $335: $382: $468: $563: $593 $542 - - Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human $56: $59: $68: $74: $79 $72 - - Stem Cell Research - Nonembryonic - Human $457: $484: $518: $569: $605 NIH is one of the world's foremost medical research centers. Stoehr A, Yang Y, Patel S, Evangelista AM, Aponte A, Wang G, Liu P, Boylston J, Kloner PH, Lin Y, Gucek M, Zhu J, Murphy E. Cardiovasc Res NIH Human Embryonic Stem Cell Registry The lines listed below are eligible for use in NIH … Twitter The Guidelines apply to the expenditure of NIH funds for research using hESCs and certain uses of induced pluripotent stem cells. The NIH published its guidelines on July 7, 2009. Nat Med J Vis Exp IPSCs can be used as a tool to study human diseases, for drug discovery, and to develop cell … In 2014, Dr. Kapil Bharti at the National Eye Institute (NEI) received a four-year Therapeutic Challenge Award to move his research beyond the pilot stage toward the clinical use. 6/13/2018 1:09 PM, Connect With Us:

Modeling Smith-Lemli-Opitz syndrome with induced pluripotent stem cells reveals a causal role for Wnt/β-catenin defects in neuronal cholesterol synthesis phenotypes. Stem Cell Research. Pinterest Pluripotent stem cells, including human embryonic stem cells (hESC) and induced pluripotent stem cells (iPSC) afford a unique opportunity for investigators to address fundamental research questions of central interest to NIGMS.

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