Some studies have suggested that using peripheral blood cells rather than bone marrow was associated with more severe GVHD. First-line allogeneic hematopoietic stem cell transplantation of HLA-matched sibling donors compared with first-line ciclosporin and/or antithymocyte or antilymphocyte globulin for acquired severe aplastic anemia. Khan F, Agarwal A, Agrawal S . A comparison of post-transplantation cyclophosphamide versus antithymocyte-globulin in patients with hematological malignancies undergoing HLA-matched unrelated donor transplantation. In other cases, people who have had had high doses of radiation or chemotherapy to destroy life-threatening cancer cells, the treatment can stop their bone marrow's ability to make blood cells. All seven of these patients experienced relapsed disease shortly after the detection of the recipient chimerism in the BM. Zhao S, Gu Z, Wang L, Guan L, Wang F, Yang N, Luo L, Gao Z, Song Y, Wang L, Liu D, Gao C. Oncotarget. Studies of clinical and immunologic aspects of allogeneic hematopoietic cell transplantation with nonmyeloablative conditioning. PubMed Google Scholar.

Because there were many tied observations at 0, the method by Bauer2 was used to obtain the exact confidence interval for differences. 2003 Nov-Dec;34(6):545-53. doi: 10.1016/j.arcmed.2003.07.002.

The process of donating peripheral blood stem cells includes taking medication -- granulocyte colony-stimulating factor or GCSF -- for four or five days, which typically causes five days of slowly building bone and muscle pain, explained Appelbaum.

Choice of conditioning regimens for bone marrow transplantation in severe aplastic anemia. The advantage for recipients of bone marrow over peripheral blood was maintained above the age of 50 years (69% versus 39%, P=0.01). Chronic GVHD typically occurs between three months to three years after the transplant. Stem cell transplants allow physicians to replace the body's source of blood cells after the bone marrow and its stem cells have been destroyed. ISSN 1476-5365 (online), Comparison of peripheral blood and bone marrow samples for detection of post transplant mixed chimerism, Short Tandem Repeats (STRs) as Biomarkers for the Quantitative Follow-Up of Chimerism after Stem Cell Transplantation: Methodological Considerations and Clinical Application, Is microchimerism a sign of imminent disease recurrence after allogeneic hematopoietic stem cell transplantation? Leukemia 15, 686–687 (2001). And "More information" links may no longer work. 2011 Jul;17(7):1018-24. doi: 10.1016/j.bbmt.2010.10.029. Although performing frequent BM examination might not be clinically feasible, further studies comparing BM chimerism to peripheral blood are warranted. Peripheral stem cell/bone marrow/cord blood. Eight samples had less recipient DNA detected in the marrow compared to the peripheral blood, … Similar survival following HLA-identical sibling transplantation for standard indication in children with haematologic malignancies: a single center comparison of mobilized peripheral blood stem cell with bone marrow transplantation. Bone Marrow Transplant. Underlying diagnoses consisted of acute myelogenous leukemia (n=16), non-Hodgkin's lymphoma (n=9), acute lymphoblastic leukemia (n=6), multiple myeloma (n=6), chronic myelogenous leukemia (n=6), severe aplastic anemia (n=4) and myelodysplastic syndrome (n=2). The biggest impact on outcome with the use of peripheral blood was seen in those patients who had a poor prognosis, ie those with advanced disease at the time of transplant. Sirinoglu Demiriz I, Tekgunduz E, Altuntas F. Bone Marrow Res. (A) Actuarial survival of all patients stratified by negative predictors of survival: interval diagnosis-transplant (Dx-Tx) ≥114 days, recipients’ age ≥20 years, no anti-thymocyte globulin (ATG) in the conditioning, a conditioning regimen other than cyclophosphamide 200 mg/kg. No matter how the stem cells are harvested, the recipient is first treated with high-dose anticancer drugs and/or radiation, and then receives the donor cells through an intravenous infusion. One limitation of our study is its retrospective nature and that not all patients in our program had simultaneous peripheral blood and BM examination. 2002 Oct 10;82(19):1306-9. NIH We analyzed 1886 patients with acquired aplastic anemia who received a first transplant from a human leukocyte antigen identical sibling between 1999 and 2009, with either bone marrow (n=1163) or peripheral blood (n=723) as the source of stem cells. 2014 Dec;28(6):1145-55. doi: 10.1016/j.hoc.2014.08.004. This study shows that bone marrow should be the preferred stem cell source for matched sibling transplants in acquired aplastic anemia, in patients of all age groups. NIH Get the latest research from NIH: https://www.nih.gov/coronavirus. Review of their role and potential in the era of cellular therapies. Seven of those patients had malignant disorders and one patient had aplastic anemia. A recent study in CML patients suggested that PBSC transplantation was associated with a decrease in PCR-positive relapse compared to marrow.8 Cytogenetic relapse was also decreased in those patients who received a peripheral blood graft. F1000Res. Appelbaum said that the results of the study should change practice. The dotted gray lines indicate a difference of ±3 percentage points.

Two to 4 μl of the 50 μl reaction were subjected to capillary electrophoresis on an ABI 3130xl Genetic Analyzer, and the unique DNA fingerprint patterns for all specimens were characterized using the fragment analysis program GeneMapper v3.7 (Applied Biosystems). Patients who were entered on trial were stratified for age and disease stage. Patients receiving peripheral blood (PB-hashed bars) transplants had significantly higher risks of acute GvHD grade II–IV, III–IV, overall chronic GvHD and extensive chronic GvHD, as compared to patients receiving bone marrow (BM-black bars). These patients had improved survival with peripheral blood compared to marrow (P < 0.04) with a decrease in regimen-related toxicity, infection, and relapse.4, There are several potential explanations for why the use of PBSC may not be associated with a higher incidence of GVHD. Chu R, Brazauskas R, Kan F, Bashey A, Bredeson C, Camitta B, Chiang KY, Frangoul H, Gale RP, Gee A, George B, Goldman FD, Gross TG, Gupta V, Hale GA, Isola L, Ispizua AU, Lazarus H, Marsh J, Russell J, Sabloff M, Waller EK, Eapen M. Biol Blood Marrow Transplant.

https://doi.org/10.1038/sj.leu.2402086, DOI: https://doi.org/10.1038/sj.leu.2402086, Leukemia Twenty-one samples had more recipient DNA detected in the marrow than in the blood. Thus, despite the large infusion of T cells, CMV reactivation after peripheral stem cell reinfusion was similar to what is observed after marrow transplant, and suggests that screening and intervention strategies should be the same for patients receiving either PBSC or marrow products.  |  Department of Pathology, Vanderbilt University Medical Center and Vanderbilt Children's Hospital, Nashville, TN, USA, Department of Pediatrics, Vanderbilt University Medical Center and Vanderbilt Children's Hospital, Nashville, TN, USA, Department of Biostatistics, Vanderbilt University Medical Center and Vanderbilt Children's Hospital, Nashville, TN, USA, Department of Pediatric Stem Cell Transplant, Vanderbilt University Medical Center and Vanderbilt Children's Hospital, Nashville, TN, USA, You can also search for this author in Hematol Oncol Clin North Am. Molecular analysis for donor–recipient chimerism after allogeneic SCT is an important component of routine monitoring and can assist in the detection of early disease relapse. doi: 10.1097/MD.0000000000021571. 2020 Jan 17;9:F1000 Faculty Rev-26. Haematologica. Molloy K, Goulden N, Lawler M, Cornish J, Oakhill A, Pamphilon D et al. But he's unsure whether it will. Another factor may be that patients recover their blood counts faster after peripheral blood transplant, thus decreasing the risk of infection and other complications that might have an impact on GVHD, including the ability to utilize adequate doses of immunosuppression. eCollection 2020. Mahmoud HK, Fathy GM, Elhaddad A, Fahmy OA, Abdel-Mooti M, Abdelfattah R, Bokhary M. Mediterr J Hematol Infect Dis.

HHS Major causes of death were graft-versus-host disease (2% versus 6% in bone marrow and peripheral blood recipients, respectively), infections (6% versus 13%), and graft rejection (1.5% versus 2.5%). Aplastic Anemia Working Party of the European Group for Blood and Marrow Transplantation (WPSAA-EBMT), See this image and copyright information in PMC.

2020 Apr;99(14):e19807. Background: For this reason, we wanted to evaluate the sensitivity of detecting mixed chimerism in BM samples as compared to peripheral blood. HHS Design and methods: But a key question has remained unanswered: Is it better to get the stem cells from a donor's blood or from bone marrow? Biol Blood Marrow Transplant 2001; 7: 473–485. Patients receiving peripheral blood…, Actuarial survival for the whole cohort of patients stratified, in univariate analysis, according…, Actuarial survival of patients receiving…, Actuarial survival of patients receiving peripheral blood (PB) or bone marrow (BM) transplants,…, (A) Actuarial survival of all patients stratified by negative predictors of survival: interval…, NLM

Peripheral blood vs bone marrow as a source for allogeneic hematopoietic stem cell transplantation. Bader P, Beck J, Frey A, Schlegel PG, Hebarth H, Handgretinger R et al. A stem cell transplant, also called a bone marrow transplant, can be used to treat certain types of cancer.

This site needs JavaScript to work properly. Chen Y, Huang X, Xu L, Liu D, Zhang Y, Ren H, Guo N, Lu D. Zhonghua Yi Xue Za Zhi. Severe acute GVHD (II–IV) was the same (13% vs 16%) in both groups (P = 0.56) and the rate of chronic GVHD was 28% for bone marrow and 38% for peripheral blood (P = 0.94).4, In terms of outcome, there was an overall greater probability of death among the recipients of marrow (P < 0.02).  |  Champlin RE, Schmitz N, Horowitz MM, Chapuis B, Chopra R, Cornelissen JJ, Gale RP, Goldman JM, Loberiza FR Jr, Hertenstein B, Klein JP, Montserrat E, Zhang MJ, Ringdén O, Tomany SC, Rowlings PA, Van Hoef ME, Gratwohl A. Arch Med Res.


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