00:22:05.00 We can culture these stem cells much the same way that Howard Green cultured epidermal stem cells 00:32:33.28 in terms of what induced pluripotent stem cells could do. 00:15:54.24 is receiving inhibitory signals from the microenvironment,

HHS

00:00:30.25 We cannot get rid of those fundamental mechanisms; they're essential to life.

doi: 10.15252/embr.201948566. 00:43:10.20 Sox9 in bone stem cells.

00:32:47.23 And the answer to that experiment was quite remarkable.

00:29:02.03 a group of transcription factors that I've shown you here. 00:09:48.07 and could be the roots of metastasis. Whew—you still with us?

00:22:54.04 that stimulate those stem cells to be able to make hair, but also to be able to make epidermis Building on years of groundbreaking discoveries in stem cell research, scientists from Indiana University School of Medicine and Harvard Medical School have determined how to grow hairy skin using human stem cells—developing one of the most complex skin models in the world.

00:01:49.22 They're there for the long haul, so they can acquire the mutations that ultimately

00:04:02.28 One of the interesting new sets of genes that are important in the squamous cell carcinoma
MCB-1052331. 00:05:35.28 And we just use a fluorescent red protein as a control.

00:26:43.21 was able to reprogram those adult skin cells into becoming an embryonic-like cell Fuchs’ lab has studied hair follicle stem cells for many years and has identified the signals that activate hair follicle stem cells as well as the specific set of transcription factors that are upregulated in the activated stem cells. 00:01:16.02 So then, it was about 30 years later when this person, Alexander Maximow, was a... 00:20:44.11 What are the microRNAs that are drivers of squamous cell carcinoma? 00:41:46.15 the autoimmune attack, those cells will still be subject to the same types of attack 00:28:09.12 Sox9 represses the epidermal stem cell differentiation program.
Radiat Res. 00:10:19.23 that were then grafted onto this patient.

00:16:40.22 So, we know a lot about the skin stem cells from my laboratory and other laboratories' research 00:29:11.27 OCT4, SOX2, and cMyc. 00:16:57.09 and the dermis. 00:41:32.23 and that the autoimmune cells... that the immune cells of the patient are

00:51:01.04 And the epithelium, the epidermal stem cells, respond by trying to repair that barrier

00:12:39.13 nasty stuff from healthy stem cells. 00:09:17.21 The stem cells only divide relatively sparingly in most situations. 00:49:48.24 I've also told you that trained immunity, the memory of inflammation, is not a phenomenon 00:09:30.26 and started to invade the stroma. and stem cell expert says that actual human stem cells can disrupt the skincare industry, but only under three conditions: they’ll need to be from a human who is preferably the one seeking the treatment, alive, and delivered directly to the skin (most likely with an injection). 00:20:56.18 in the skin epithelium? ESCs are special because they can generate all the different tissues of the body, thus providing great potential for use in regenerative medicine. 00:21:21.04 and why we continue to use it as an important model to be able to uncover Unraveling Immune-Epithelial Interactions in Skin Homeostasis and Injury. 00:31:57.03 And so, when the stem cells of the hair follicle are unable to be able to produce hair, Cell. NLM 00:04:28.04 and the hairs of our body. Green H, Kehinde O, Thomas J. 00:49:26.15 I've told you that key stem cell genes are regulated by super enhancers that bind stem cell Notice how it's a human stem cell-derived media and not an actual human stem cell. 00:01:30.20 And just looking underneath the microscope at bone marrow cells, he saw some cells Takahashi K, Yamanaka S. (2006) Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. 00:50:39.22 And remember that the most important thing that the skin epithelium does is -, Wikramanayake T.C., Stojadinovic O., Tomic-Canic M. Epidermal differentiation in barrier maintenance and wound healing. 00:40:18.27 "super enhancers". 00:40:45.26 the hair follicle stem cells in their quiescent, undifferentiated state. 00:07:28.23 that Howard Green had performed, in this case, to culture cornea or corneal epithelial cells

00:07:13.04 Michele De Luca and Graziella Pellegrini, who were then studying in Howard Green's laboratory 00:09:02.16 cells of a tissue.


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