In 2000, Long et al 37) used an ultrasensitive ELISA and found that AMH levels became undetectable in 15 of 16 women treated for granulosa cell tumors and were elevated in 14 of 15 women (sensitivity 93%) with recurrent granulosa cell tumors. A late metastasizing tumour. Eight of 14 had no response to treatment and had a median survival of 12.3 months overall 41). They secrete inhibin, a protein that suppresses pituitary release of follicle-stimulating hormone (FSH). The majority of cases (80-90%) of granulosa cell tumor of the ovary are stage 1 at diagnosis (cancer is still contained within the ovary and has not spread). Adult granulosa cell tumor. Sertoli-leydig tumours can be either benign or cancerous. Rubin SC, Sabbatini P, Randall ME. If you want more support I recently set up a closed FB group called UK GCT Survivor Sisters! 1996;61:227–32. Because most tumors are stage Ia (see Staging), a unilateral salpingo-oophorectomy is sufficient treatment for most patients. They make the female hormone oestrogen which can cause symptoms such as abnormal vaginal bleeding or breast tenderness. I have a feeling she won't want to see me, as I was kind of discharged from their care before my pregnancy. They went in and found 7 more tumors. Then you could have knocked us and our consultant down with a feather!!! East N, Alobaid A, Goffin F, Ouallouche K, Gauthier P. Granulosa cell tumour: a recurrence 40 years after initial diagnosis. Juvenile granulosa cell tumor of the ovary. Delaying adjunct therapy until after delivery is not well studied but could be considered because many of these tumors exhibit indolent growth. [Medline]. You can share experiences, stories and information with other people who know what you are going through. You have several days of chemotherapy at the beginning of the cycle and then a break until the start of the next cycle. Stage 3a: Tumor is grossly confined to the pelvis but with microscopic seeding of the abdominal peritoneal surfaces. Moreover, only 2 of the 103 patients received chemotherapy 43).

Some women need chemotherapy after surgery. Am J Obstet Gynecol. [Medline].

Aromatase Inhibitor Therapy As Effective Rescue in a Patient With Tamoxifen-Refractory Metastatic Granulosa Cell Tumor of the Ovary. Adult granulosa cell tumor. A bimanual examination and a rectovaginal examination should be performed to evaluate the pelvis and lower abdomen for masses, the posterior cul-de-sac for nodularity, and any other areas associated with tenderness.

Prognostic factors responsible for survival in sex cord stromal tumors of the ovary–a multivariate analysis. [Medline]. It is hard to organise and run trials for rare cancers.

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