In adults, hematopoiesis occurs in bone marrow and generates hundreds of millions of new blood cells every day. Prenatally, hematopoiesis occurs in the yolk sack, then in the liver, and lastly in the bone marrow.In the normal situation, hematopoiesis in adults occurs in the bone marrow and lymphatic tissues. This is the term used for blood cell production that occurs outside of the bone marrow.

Fetal hematopoiesis occurs first in yolk sac of the embryo from where it migrates to the fetal liver (FL) and finally to BM for the initiation of definitive hematopoiesis. Bone Marrow. It can be seen in chronic anemia, with the production of blood cells in the liver, spleen and sometimes in the lymph nodes. It occurs in the bone marrow, spleen, liver, and other organs. As the organism develops past the embryonic stage, hematopoiesis requires the use of multipotential hematopoietic stem cells and is termed definitive hematopoiesis. Extramedullary Hematopoiesis . hematopoiesis [he″mah-to-poi-e´sis] the formation and development of blood cells. In other scenarios, there may be malignant hematopoietic cells located in areas outside of the bone marrow.

In the embryo and fetus it takes place in a variety of sites including the liver, spleen, thymus, lymph nodes, and bone marrow; from birth throughout the rest of life it is mainly in the bone marrow with a small amount occurring in lymph nodes. Hematopoiesis is the process by which the body produces blood cells and blood plasma. All cellular blood components are derived from haematopoietic stem cells. It occurs in more than one anatomical site of mammalian system, and based on the site, it is classified as fetal (primitive) and adult (definitive). At birth hematopoiesis is restricted primarily to the marrow, although occasional areas of extramedullary hematopoiesis may be found in the spleen or liver. Hematopoiesis in the fetus occurs in multiple organs besides the bone marrow, including the thymic anlage, primordial lymph nodes, liver, spleen, kidney, and adrenals (Valli, 2007). It is found between the trabeculae of the spongy portions of bones. Hematopoiesis: The production of all types of blood cells including formation, development, and differentiation of blood cells. In a healthy adult person, approximately 1011–1012 new blood cells are produced daily in order to maintain steady state levels in the peripheral circulation. Haematopoiesis is the formation of blood cellular components.

Although the process of hematopoiesis is initiated in the bone marrow, further maturation occurs in other lymphoid organs, including the spleen, thymus, and lymph nodes. Bone marrow is a specialized connective tissue composed of developing blood cells within a supportive stroma of reticular tissue.

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