Alleles listed retain their link to the IMGT/HLA database (http://www.ebi.ac.uk/ipd/imgt/hla/allele.html) Because the variations in the three intermediate alleles impact the amino acid sequences of the ARD, in addition to their questionable impact on protein expression, the lack of information on expression should not hinder decisions regarding their relevance in matching. Ancestry categorization was defined by each registry and converted into seven population groups for this study: AFA (African/African American), API (Asian/Pacific Islands), EURO (European/European descent), MENA (Middle East/North Coast of Africa), HIS (South or Central America/Hispanic/Latino), NAM (Native American) and UNK (unknown/not asked/multiple ancestries/other).

Self‐identification of ancestry does not necessarily reflect genetic ancestry.25 In cases where the ancestry of a patient or donor may not be known, the laboratory might, for example, rely on the highest frequency CIWD listings to determine if further typing resolution is needed.

Therefore, most registries are typing at a resolution of A*02:01:01G so there are insufficient data to accurately assess the frequency of A*02:01:01:01 in this dataset. Support for the OnlineOpen status of Mack et. (g) Assignment of novel alleles are assignments without a nomenclature designation; these assignments were merged (eg, A*NEW) and included in the analysis. Abbreviations: C, common; I, intermediate; WD, well‐documented; ND, not determined.

This catalog, CIWD version 3.0.0, is a step closer to the collection of global HLA frequencies and to a clearer view of HLA diversity in the human population as a whole. Alleles not included in the CWD manuscript are listed for reference.

For example, the A*02:49:01G group includes A*02:49 and A*02:683.

replace the National Marrow Donor Program's Biannual Rare Alleles Lists. Immunogenetics in stem cell donor registry work: The DKMS example (Part 2).

Two (B*08:12 (AFA), B*37:04 (API)) were considered not‐CWD in 2.0.0 CWD, likely because of the limited population groups included at that time. Although this analysis represents the largest catalog of the frequency of alleles to date, the data are heavily represented from registries in the United States and Germany. HLA‐DRB3/4/5 two‐field groups are only categorized as well‐documented because of incomplete information at these loci. In contrast, A*02:01:01G appears at frequency of >1 in 4 (0.27) in Europeans. Table 3 describes the overall frequency of alleles at each locus observed compared with the total number of alleles in IPD‐IMGT/HLA 3.31.0. Learn more. We offer the most comprehensive and collaborative CWD catalog to date through the efforts of the 18th International HLA and Immunogenetics Workshop and the World Marrow Donor Association participating registries.

Bill Young Cell Transplantation Program. In the United States, for example, 13% of individuals were born in another country and 25% of individuals list multiple ancestries (https://www.census.gov, October 2018).

The sources of data used for this and the three earlier catalogs differ dramatically although all included some evaluation of unrelated hematopoietic stem cell donors (Supporting Information Table S1). For examples, DQB1*03:27, listed as well‐documented in China CWD, was observed three times in this registry study dataset (found in API), and DQB1*06:19, listed as well‐documented in EFI CWD, was observed four times (API/EURO‐2/UNK).

The novel allele identified in a Saudi individual. Alleles listed retain their link to the IMGT/HLA database

The remainder of the alleles were classified as not‐CWD.

Alleles where variation potentially impacting protein expression has been described but not yet documented by further studies (ie, alleles with a Q designation) total 14 in the CIWD category. Variation in the ability to assign polymorphic residues to one haplotype vs the other has also varied with the reagents and methods used producing, in many cases, ambiguity in the specific genotype carried by an individual. Nomenclature of HLA Alleles Early in their study, it was recognised that the genes encoding the HLA molecules were highly polymorphic and that there was a need for a systematic nomenclature. News www.hlacovid19.org website. Similar findings are provided for HLA‐A, ‐C, ‐DRB1, and ‐DPB1 (Tables 3 and 4, Figure 1, Supporting Information Table S3a, c, d, g). In the IPD‐IMGT/HLA database,11 the CWD status of alleles has been updated as additional fields are added to the allele name.

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