For enquiries, contact us. Not all products will be made available in all jurisdictions and availability of some products may be limited; therefore, officials in individual provinces and territories should be consulted regarding the products available in individual jurisdictions. �J]� ��JU�O���P��)R`MH��Yi�dhˠzs�s*��:�3�)� �O7�P�[l(��z��ڲ,Ɩ!�0�M3C-3�#s�j��i�����8�����2k����.w��j$�Nx(�z�����9Q'�sw���m�;lK��M����ɁS-e�����e�m_��Z3��P%c;W�Q�MlgF�Q\�h�+>3�����TXբ����?������ In addition, as a precautionary measure, LAIV recipients should avoid close association with people with severe immune compromising conditions (e.g., bone marrow transplant recipients requiring isolation) for at least 2 weeks following vaccination, because of the theoretical risk for transmitting a vaccine virus and causing infection. In older adults, VE of IIV3-SD is about half of that in healthy adults and varies depending on the outcome measures and the study populationFootnote 98,Footnote 99.

Available from: http://www.statcan.gc.ca/pub/82-625-x/2014001/article/11896-eng.htm, Schanzer DL, McGeer A, Morris K. Statistical estimates of respiratory admissions attributable to seasonal and pandemic influenza for Canada. Effectiveness of influenza vaccination. Vaccination is recommended for contacts, both adults and children, of individuals at high risk of influenza-related complications or hospitalization (see List 1), whether or not the individual at high risk has been vaccinated. A trivalent product (IIV3-HD; Fluzone® High-Dose) for adults 65 years of age and older is available.
MF59 further facilitates the internalization of antigen by these dendritic cellsFootnote 115,Footnote 117. N Engl J Med. 1997;175(1):1-6, Lemaitre M, Meret T, Rothan-Tondeur M, Belmin J, Lejonc JL, Luquel L, Piette F, Salom M, Verny M, Vetel JM, Veyssier P. Effect of influenza vaccination of nursing home staff on mortality of residents: a cluster-randomized trial.

NACI members and liaison members conduct themselves within the context of PHAC’s Policy on Conflict of Interest, including yearly declaration of potential conflict of interest. Refer to the NACI Literature Review Update on the Efficacy and Effectiveness of High-Dose and MF59-Adjuvanted Trivalent Inactivated Influenza Vaccines in Adults 65 Years of Age and Older for more information on the efficacy and effectiveness of IIV3-HD in adults 65 years of age and older. Due to a lack of available data directly comparing the performance of IIV3-Adj, IIV3-HD, and IIV4-SD, considerations for these vaccines in Table 4 are compared to IIV3-SD for which comparative data on efficacy, effectiveness, and/or immunogenicity with each of IIV3-Adj, IIV3-HD, and IIV4-SD are available. As noted in PHAC’s Guidance: Infection Prevention and Control Measures for Healthcare Workers in Acute Care and Long-term Care Settings for seasonal influenza, all health care organizations should have a written plan for managing an influenza outbreak in their facilities. The amount of trace ovalbumin allowed in influenza vaccines that are authorized for use in Canada is associated with a low risk of adverse events. Young children have a high burden of illness and their vaccine-induced immune response is not as robust as older children. NACI has not assessed the comparative cost-effectiveness of available influenza vaccine types for children 2–17 years of age. Abbreviations: FFU: fluorescent focus units; HA: hemagglutinin; IIV3-Adj: adjuvanted trivalent inactivated influenza vaccine; IIV3-HD: high-dose trivalent inactivated influenza vaccine; IIV3-SD: standard-dose trivalent inactivated influenza vaccine; IIV4-SD: standard-dose quadrivalent inactivated influenza vaccine; IM: intramuscular; LAIV4: quadrivalent live attenuated influenza vaccine; NA: neuraminidase. Even when there is a less-than-ideal match or lower effectiveness against one strain, the possibility of lower VE should not preclude vaccination, particularly for people at high risk of influenza-related complications and hospitalization, since vaccinated individuals are still more likely to be protected compared to those who are unvaccinated. Large cohort studies of administrative health databases have found no association between childhood vaccination with thimerosal-containing vaccines and neurodevelopmental outcomes, including autistic-spectrum disordersFootnote 13. Inactivated influenza vaccine effectiveness against influenza-like illness among young children in Japan--with special reference to minimizing outcome misclassification.
2015;211(10):1529-40, McLean HQ, Thompson MG, Sundaram ME, Meece JK, McClure DL, Friedrich TC, Belongia EA.

Geometric mean titre ratios (GMTR) of participants’ responses to high- versus standard-dose influenza vaccines were reported in several studies and were calculated for those that provided group-specific, post-vaccination titres for each of the vaccinesFootnote 128,Footnote 129,Footnote 130,Footnote 131,Footnote 132,Footnote 134,Footnote 135.

Vaccine effectiveness against medically attended, laboratory-confirmed influenza among children aged 6 to 59 months, 2003-2004. Influenza A viruses are classified into subtypes based on two surface proteins: hemagglutinin (HA) and neuraminidase (NA).


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