REVLIMID is indicated as maintenance therapy in adult patients with MM following autologous hematopoietic stem cell transplantation (auto-HSCT). Monoclonal antibodies – Antibodies are substances produced by the immune system to fight off viruses, bacteria and other foreign substances. Do not use REVLIMID during pregnancy. Thyroid Disorders: Both hypothyroidism and hyperthyroidism have been reported. Bi-specific T cell-engaging antibodies (BiTEs) bind both cancer cells and T cells in order to help the immune system respond more quickly and effectively. Multiple myeloma (MM), a bone marrow–resident hematological malignancy of plasma cells, has remained largely incurable despite dramatic improvements in patient outcomes in the era of myeloma-targeted and immunomodulatory agents. Myeloma—also referred to as multiple myeloma or plasma cell myeloma—is a cancer that originates in plasma cells, a type of white blood cell found in the bone marrow that makes antibodies.

In the U.S., it is estimated that 1 in 132 men and women will develop myeloma at some point in their lifetimes. For additional information, review our Privacy Policy. REVLIMID is only available through a restricted distribution program, REVLIMID REMS®. Avoid concomitant use of POMALYST with strong inhibitors of CYP1A2. Cytokines regulate immune cell maturation, growth, and responsiveness. Treatment of patients with MM with a PD-1 or PD-L1 blocking antibody in combination with a thalidomide analogue plus dexamethasone is not recommended outside of controlled clinical trials. A secure website for patients to access their medical care at Moffitt. POMALYST® (pomalidomide) is a thalidomide analogue indicated, in combination with dexamethasone, for patients with multiple myeloma who have received at least two prior therapies including lenalidomide and a proteasome inhibitor and have demonstrated disease progression on or within 60 days of completion of the last therapy. An online resource for referring physicians and their staff. In patients with MM, MDS was also observed. erythropoietin-stimulating agents (ESAs) and estrogens may further increase the risk of thrombosis and their use should be based on a benefit-risk decision. For people with multiple myeloma, abnormal plasma cells grow uncontrollably and crowd out healthy cells, including other types of white blood cells, platelets and red blood cells, which can lead to bone and calcium issues, low blood counts, kidney problems and infections. In CAR T cell therapy, T cells are modified and equipped with chimeric antigen receptors (CARs) that enable superior anti-cancer activity. Hearn Jay Cho, M.D., Ph.D., at Mount Sinai School of Medicine, discovered that two of the type I Melanoma Antigen Genes (MAGE), MAGE-A3 and CT7/MAGE-C1, are expressed in the tumors of more than 75 percent of myeloma patients, and demonstrated that MAGE-A3 is a critical survival factor in multiple myeloma that makes these cells resistant to normal cell death and killing by chemotherapy agents, providing further evidence that MAGE proteins may be excellent candidates for tumor vaccines targeting multiple myeloma.

Immunotherapy can be used for multiple myeloma treatment and is often recommended as part of first line therapy, or after stem cell transplantation as part of a comprehensive treatment plan. Patient Appointment Center Hours: 7 a.m. to 7 p.m. Monday - Friday; 8 a.m. to noon Saturday, STORIES TO INSPIRE YOU ON YOUR JOURNEY THROUGH CANCER, Immunomodulatory agents (IMIDs): These agents exert their biologic effect against myeloma partly by stimulating the patient’s own immune cells. "Cancer research not only saved my life but will potentially save members of my family.". *Immunotherapy results may vary from patient to patient.

This September for Blood Cancer Awareness Month, we look at how we’re workin... Immunotherapy Research Helping Confront COVID-19. After return to baseline values, treatment at a lower dose may be considered. In addition to the FDA-approved therapies listed above, there are several new classes of myeloma immunotherapy in clinical trials. Copyright © 2020 Cancer Research Institute | Privacy Policy | Accessibility Statement. Plasma cells produce antibodies and play an important role in the body’s immune system function.


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