Dissecting the genomic complexity underlying medulloblastoma. doi: 10.1016/S1470-2045(19)30669-2.

In the case presented, the patient had a first recurrence after a disease-free interval of 6 years. Medulloblastoma cell lines present both VEGFR-1 and VEGFR-2. Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Significant differences in the The Lancet Regional Health – Western Pacific, Advancing women in science, medicine and global health, Abiraterone acetate plus prednisone versus prednisone alone in chemotherapy-naive men with metastatic castration-resistant prostate cancer: patient-reported outcome results of a randomised phase 3 trial, Perioperative FOLFOX4 chemotherapy and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC 40983): long-term results of a randomised, controlled, phase 3 trial, Access any 5 articles from the Lancet Family of journals, https://doi.org/10.1016/S1470-2045(13)70449-2, Recurrence patterns across medulloblastoma subgroups: an integrated clinical and molecular analysis, Correction to Lancet Oncol 2013; 14: 1205, The Lancet Regional Health – Western Pacific, Recommend Lancet journals to your librarian. Outcome prediction in pediatric medulloblastoma based on DNA copy-number aberrations of chromosomes 6q and 17q and the MYC and MYCN loci.

For that reason, in view of the short relapse-free interval and of the lack of response to the conventional chemotherapeutic drugs, we decided to enter the patient into an off-label treatment with bevacizumab. Thus, he received chemotherapy with dacarbazine-etoposide-cisplatin (DEC) for 6 cycles; after four cycles of this treatment a grade III-IV neurotoxicity was developed, so carboplatin was introduced in the place of cisplatin. Subtypes of medulloblastoma have distinct developmental origins.

Adjuvant or neoadjuvant chemotherapy plays also a key role in permitting a reduction in the dose of cranio-spinal irradiation; thus, chemotherapy is to date a standard of care in pediatric medulloblastoma, whereas its role in adult setting is not determined due to the rarity of the disease. Treatment of recurrent central nervous system primitive neuroectodermal tumours in children and adolescents: results of a Children's Cancer and Leukaemia Group study. Salvage therapy for progressive, treatment-refractory or recurrent pediatric medulloblastoma: a systematic review protocol Ashley A. Adile 1 , 2 Michelle M. Kameda-Smith 1 , 3 EANO-EURACAN clinical practice guideline for diagnosis, treatment, and follow-up of post-pubertal and adult patients with medulloblastoma. of therapy for patients with group 3 or group 4 tumours should focus on metastases.

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